Question
Posted on: March 6 2013Problems with a lotion with Nystatin, erythromycin and hydrocortisone: Nystatin 2.4 million U erythromycin base 2% Locoid Crelo 100 ml milk UG 1xday ' savonds on the
Specks on the head (boy 14 years) < br/> This composition was prescribed by a dermatologist, who is unaware of the described incompatibilities between erythromycin and Hydrocortisone butyrate. Should we inform him of this in such a way that it will not be prescribed in the future? Is it useful to combine these assets? In The Demand box it is recommended to prepare a lotion with erythromycin and use it alternately with Locoid Crelo. After all, at acidic pH (Locoid Crelo (with citric acid)) erythromycin decomposes quickly. On the other hand, esters of corticosteroids such as hydrocortisone (17) Butyrate are not stable in Alcalisch center. But what about the Nystatin? Together with haemoglobin in a lotion? Nystatin was also still prescribed as a speciality syrup (2x2ml/day).
Answer
Best Prepare the Hydroalcoholic lotion with erythromycin from the TMF and add 1% hydroxypropylcellulose 400 to this lotion in order to increase the viscosity so that nystatin can be suspended. After all, Nystatin has its maximum stability at a pH of 6 à 8.
about the usefulness of the combination of these different products we can say little positive. We must refer to Apoth's response. M. Dooms at question 895. This requirement is a second example of an "always price" composition. The doctor should know that this combination is not ideal. But maybe he's end board???
about the usefulness of the combination of these different products we can say little positive. We must refer to Apoth's response. M. Dooms at question 895. This requirement is a second example of an "always price" composition. The doctor should know that this combination is not ideal. But maybe he's end board???