Question
Posted on: October 29 2015How to prepare a cream with N-acetylcysteine for the treatment of ichtyosises
Answer
The cream used in the published formula is not available to us and therefore we opt for Cremor Cetomacrogolis FN 6 with parabens as a preservative, unless there are indications for parabens. But the final pH of the cream is unfavorable to sorbic acid.
In This cream occurs approximately 65 g of water per 100 g. half of the water is used for the preparation of the cream; the other half for solving of Acetylcysteine. We replaced 5 g Vaseline by 5 G glycerin!
1. Tarreer a beaker of 150 to 200 ml together with a plastic spatula (mass = T)
2. Boil 75 ml of water and allow to cool to 70 °C
2. Melt the fat phase of the cream on a hot water bath in the tarred Beaker and add 35 ml of water (70 °C) and prepare the cream
3.. To dissolve 10 g of acetylcysteine We put in a beaker 30 g of water (35 °C) 5 g NaHCO3, 100 mg EDTA and 100 mg nametabisulfite; After solving these constituents, we add the acetylcysteine and place the whole on a magnetic stirrer; Possibly with light (35 ° C) warming
4. Once dissolved, we mix the solution with the cream and homogenize
5. We place beaker with cream and spatula on the balance and compensate for the evaporate water. Total weight T + 100