Eye ointment with Vit A for veterinary use; No longer available as a specialité.

As excipient we use the eye ointment base of the PB V (see Galenic formularium). An ointment tube without a cap, a small spatula and a glass rod are wrapped in parchment paper and sterilized for 20 minutes at 120 °C in an autoclave. Meanwhile, the required amount of the different ointment components is weighed in a clean beaker. After covering with all foil, this base is sterilized for 1 hour at 150 °C in a hot air furnace. After sterilization, the supplies are placed in the hot air oven for drying. If the sterilization time of the ointment base has expired, it can be cooled down to 60 °C. Thereafter, the required amount of Vit A oil solution is weighed at the ointment base. The whole is mixed with the sterile spatula. The cap of the ointment tube is washed out with antiseptic solution and after fast air drying on the sterilized ointment tube rotated. The ointment tube is placed upright on the balance and 10 g of ointment is poured into the ointment tube along the sterilized glass rod. Eventually the ointment tube is closed and labelled.

Comments:

1. the Pharmacopoeia limits the delivered amount of eye ointment to 10 g;
2. the large size work makes it profitable to fill different tubes of 10 g. This will also increase the amount of Vit A oil solution to weigh.
3. Optimal is of course the use of a LAF cabinet for weighing and blending the Vit A. The balance in the LAF cabinet is drawn up for the distribution of the prepared eye ointment over different tubes.
4. This method of preparation is susceptible to criticism as it can be noted that there may be problems in terms of homogeneity when cooling the ointment base to room temperature without further mixing. We are with the heavy problem of aseptic filling in the ointment tubes! This I have been trying to bypass.