Question
Posted on: March 6 2013This cream from the polypharmacy breaks! Saponinecoaltar 5g Salicylic Acid 8g Ureum 8g Zinc sulfate 300mg chlorbutol 5g methylprednisolone 320mg dexamethasone 160mg
Betamethasonediprop 120mg
cetylalkohol 17g
white Vaseline 21g
glycerol 15g
Cetomacrogol 1000 3.6 g
water ad 100gr < BR/> First tried to make the ointment base. This is OK. Adding the solids does not give any problems but when adding the saponinecoaltar it is getting wrong. After some time, a purple discoloration occurs. Any suggestion to add the Saponinecoaltar to the preparation?
cetylalkohol 17g
white Vaseline 21g
glycerol 15g
Cetomacrogol 1000 3.6 g
water ad 100gr < BR/> First tried to make the ointment base. This is OK. Adding the solids does not give any problems but when adding the saponinecoaltar it is getting wrong. After some time, a purple discoloration occurs. Any suggestion to add the Saponinecoaltar to the preparation?
Answer
That the CR è me breaks is one for me at first sight a surprise. Indeed, all present emulsifiers, including Saponinecoaltar, point in the same direction, namely the formation of an O/W emulsion. But I suspect that ZnSO4 might be the disturbing element by the reaction with the ammonium salts present in LCD. If Zn salts are indeed formed then these are supposedly a W/O emulsifying character and we get a conflict of opposing emulsifiers.
so I would start the preparation of the CR è me without the expensive Corticostero ï den and without the znsulfate and the salicylic acid. I suppose this will succeed. The salicylic acid can then be mixed with half of the prepared CR è me (divided into fractions).
the remaining half can be mixed with LCD. And we look forward to the result. Based on this preview, you can then become obsolete which product is the disturbing factor.
The purple color is probably due to the reaction of salicylic acid with iron ions. I am not clear from where they come from. Maybe 1% add NaEDTA?
so I would start the preparation of the CR è me without the expensive Corticostero ï den and without the znsulfate and the salicylic acid. I suppose this will succeed. The salicylic acid can then be mixed with half of the prepared CR è me (divided into fractions).
the remaining half can be mixed with LCD. And we look forward to the result. Based on this preview, you can then become obsolete which product is the disturbing factor.
The purple color is probably due to the reaction of salicylic acid with iron ions. I am not clear from where they come from. Maybe 1% add NaEDTA?