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Question

Posted on: March 6 2013

Could it be that there are incompatibilities in the following formula, because our result was not supreme. From an NKO-doctor we received following recipe: Fluimucil 3 vials of Eucalyptol

200 mg
Na borate 500 mg
Ephedrine Base 200 mg
Adrenaline 1 0/00 5 dr
Vaseline 20 g
Sweet Almond oil 10g
FAC/nasal ointment with cannula < BR/>

Answer

There are two possible solutions to prepare a nice preparation.

  1. The first possibility exists in solving the Fluimicil in a minimum solvent, which is provided with the gelyofilized powder. This solution is then emulated in the fatty base consisting of petroleum jelly and sweet almond oil. Of course, a W/O emulsifier will need to be added. This can be e.g. a 0.5 g Arlacel C. The amount of petroleum jelly is then placed at 19.5 g. The addition of the adrenalin solution will also run smoothly.

  2. But there is a second allight better possibility. Here the Fluimicil is now processed as a dry substance in the fat phase. The adrenaline solution is now replaced by an adrenaline trituration (see below) of which the equivalent of 5 drops is weighed. This method excludes the addition of all moisture, which has a beneficial effect on the stability of adrenalin and thiamphenicolglycinate Acetylcyst ï Naat!! And this certainly in the case of this formulation in which you can not prevent that naborate and ephedrine also dissolve in the aqueous phase. And both react alkaline.

The use of an adrenaline trituration is recommended also when processing adrenaline in certain formulations of hemorrhoids suppositories.

a 1:200 trituration of adrenaline is suitable to replace the 1 pro thousand solution. It is best prepared on the basis of mannitol. A quantity of 10 mg trituration corresponds to 1 drop of the solution.