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Question

Posted on: March 6 2013

Clavucid 175mg in suppositories for a child +/-2 years. Posology 3x1 per day.

We have prepared suppositories of 2 G, aangien 1 G proved impossible, but how is it set with bioavailability? Which would be the ideal suppobasis for this preparation?

Answer

There is no consensus on the rectal absorption of antibiotics. Unfortunately, I could not find any information about the rectal absorption of amoxycillin. So the clinical signs will have to show whether there is a therapeutic effect. An ideal suppository mass I can not recommend you either. In addition, the availability in Belgi ë is minimal. I would still opt for Suppocire AS2X.

ADDENDUM (Thanks to Prof. Dr. G. Laekeman)

Clinical Evaluation of Ractally Administered Ampicillin in Acute Otitis Media
B.K.V. Bergstr ö m, S.O. Bertilson and G. Movin
The Journal of International Medical Research (1988) 16:376-385.

An ampicillin suppository was compared with Amoxycillin suspension in the treatment of acute otitis media in children. Both antibiotics were given three times daily for 5 days in a daily dose of 25-50 mg/kg body weight. Safety was evaluated in 454 patients in the group given suppository and in 229 given the suspension, and 421 and 229 patients, respectively, were evaluable for efficacy. Ampicillin was rapidly absorbed and produced plasma concentrations well above the minimum inhibitory concentration for common respiratory pathogens. The overall clinical outcome was satisfactory (cured plus improved) in 89% of the patients given the suppository and in 86% given the suspension. Gastro-intestinal disturbances occurred in 28.4% of the patients given the suppository compared with 14.4% of those given the suspension. Periirritation was recorded in 12.1% of the patients given the suppository and in 5.2% of those given the suspension. Treatment was interrupted in 9.8% of patients given the suppository and in 0.9% of those given the suspension. In spite of these discomforts rectally administered ampicillin is considered to be a good alternative in children when oral medication is not feasible.