oxycodon in zetpillen

De smelttabletten zullen eerst in een minimum hoeveelheid water opgelost dienen te worden. 0,5 ml per zetpil is hopelijk voldoende om de smelttablet op te lossen. Deze oplossing wordt geëmulgeerd in de zetpilmasssa Suppocire AS2X. 

Wat de gegevens over opname betreft vond ik het volgende. Wat hier geschreven staat geldt niet noodzakelijk voor uw zetpillen maar het is een indicatie. Wat opvalt is de hoge dosis rectaal. 

Comparative Oxycodone Pharmacokibetics in Humans by Kim P. Leow, in Therapeutic Drug Monitoring 14: 479-484, 1992

Summary: The pharmacokinetics of oxycodone have been determined after single-dose administration by the intravenous (4.6-7.3 mg), oral (tablets, 9.1 mg and syrup, 9.1 mg), and rectal (30 mg) routes, in 48 patients undergoing minor surgery. There were no significant differences in the mean elimination half-Jives between the intravenous (5.45 ± 1.43 h), oral tablets (5.65 ± 1.13 h), oral syrup (4.80 ± 1.13 h), and recta! suppository (5.40 ± 1.19 h) formulations of oxycodone. After intravenous administration, the mean plasma clearance of oxycodone was 25.5 ± 10.1 LJh and the mean volume of distribution at steady state was 2.5 ± 0.8 Ukg. The meao normalized area under the curve (AUC/D) obtained after intravenous dosing (48.2 ± 30.2 µg · h/l/mg) was more than twice the AUC/D values obtained after the administration of oxycodone tablets (19.8 ± 3.5 µg · h/l/mg), oxycodone syrup (17.5 ± 5.3 µg · h/l/mg), and recta! suppository (20.3 ± 5.1 µg · h/l/mg), indicating that the amount of oxycodone reaching the systemic circulation after the extravascular routes of administra­tion was <50% of that obtained after intravenous dosing. The mean absorption Lag times after oxycodone tablets (0.52 ± 0.33 h), oxycodone syrup (0.48 ± 0.40 h), and recta! suppository (0.76 ± 0.47 h) were consistent with the onset of pharmacological effects reported by the patients.