Vraag
Gepost op: 9 april 2024azithromycine orale suspensie
om de onbeschikbaarheid van de azithromycine suspensie op te vangen kregen wij de vraag om deze magistraal te bereiden. heeft u tips daaromtrent.
Antwoord
Azithromycine 4, 0 g
Xanthaangom 500 mg
HPMC 300 mg
Na3PO4 · 12H2O 800 mg
Methyl paraben (M.P) 180 mg
Propyl paraben (P.P) 30 mg
Disodium EDTA 100 mg
Artificial flavor (raspberry flavor) 500 mg
Sacharose 93,0 g
Freshly boiled Water 40 ml
Ik denk dat deze samenstelling kan worden gebruikt
Stabiliteit
The study aimed to investigate the stability of azithromycin in a reconstituted oral suspension under various in-home storage conditions over 10 days. Azithromycin oral suspension was reconstituted by boiled tap water (200 mg/5 ml) and stored under various in-home storage conditions (exposure to sunlight, refrigerated (4°C), stored at room (20°C) and higher temperatures (30°C, 40°C and 50°C). Azithromycin concentrations in the samples of the suspension were analysed daily for 10 days using an HPLC method. The results revealed that the reconstituted azithromycin stored under various in-home storage conditions is stable for 10 days. The active molecule of azithromycin showed good stability after reconstitution with boiled tap water.
