Why is Nystatin incompatible with Carbomeergel TMF? Is there an alternative in such a way that the gel structure remains intact?

As is usually the case, the explanation must be sought using the chemical properties. The following chemical formula means that a carboxyl group is found in the complex structure.

This carboxyl group enters into competition with Carbomer for the added base. The obvious solution would be: "Replace the carbomwing gel with a non-ionogenic gel such as a HEC or HPMC gel. But perhaps a more elegant good penetrating gel can be offered by using a water-free carbomer gel as described in the article: "A New approach for compounding gels containing a non-steroidal anti-inflammatory drug." . This article is on the Web page of the International Society of Pharmaceutical Compounding or ISPhC .