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Question

Posted on: August 21 2016

What method for the next ' complex oncological wound ointment ', with Linisol and Exacyl?

Composition: Vioform 25 g; Zinc oxide 150 g; Olive oil 125 g; Linisol 2% 50 ml; Exacyl ampoules 25 ml; Orahesive Powder 25 g; White Vaseline AD 500 g (sometimes at the request of the doctor to process metronidazole in the preparation, Flagyl 500 1box) Proposed method 1. Aqueous solutions: Linisol and Exacyl ampoules mix and sprinkle on this solution ZnO; Then add olive oil 2. In mortar Vioform mix with Orahesive powder and finally the petroleum jelly How does one tackle this? Are interactions (long-term)? Shelf life?

Answer

Composition of the used specialitites  

1. Linisol = aqueous solution of lidocaineHCl 2% dissolved in aqueous solvent   pH = +/-6.5

2. Exacyl aqueous solution of tranexamic acid = amphottar molecule pKa = 4.3 and pKb = 3.4   Thus a combination of a weak acid with a weak base  

Comments  

Linisol and Exacyl immediately mixing with ZnO will cause interaction of an acidic solution with alkaline ZnO; probable formation of zntranexaminate and possibly Lidocaiine from lidocaineHCl.  

would be better ZnO together with Vioform and Orahesive powder mix in mortar   and rub with olive oil and most of the white Vaseline.

Modus Operandi

Take a mortar with pestle and taring the whole. Take note of the tare mass (= T)

Bring in the mortar Vioform and Orahesive powder and mix. Gradually add ZnO and mix until homogeneous after each addition. Rub the powder mass with olive oil into a homogeneous paste and   treat it with the ointment grinder.   If 1 box of Flagyl should be added, calculate how much metronidazole this means. Weigh this amount and rub the metronidazole into a rough mortar so that no hard grains are in the powder. Then add the metronidazole to the mixture described above so that everything is processed by the ointment roller.  

Linisol I would replace the corresponding amount of lidocaineHCl   in order to limit the amount of water in the preparation. After all, petroleum jelly is not able to absorb large amounts of water without the presence of a strong emulsifier. The 75 ml of liquid, which is present in the composition, is now likely to be adsorbed by Orahesive powder, which therefore loses adhesive power. I think the lidocaineHCl can be dissolved in 25 ml Exacyl ampules. This liquid is added to the fat mass as the very last per 5   ml and is mixed well after each addition.  

Place mortar and pestle on the balance and continue with white Vaseline to T + 500 and mix to homogeneous

Interactions

Short or long term interactions are difficult to predict but some cases are known where Zn (2 +) ions react with aniogenic polymers such as pectin, possibly gelatine. We must keep in mind that there is a little water in the whole. So I do not exclude that during storage the mass becomes more consistent and grainy. Perhaps best to deliver the first episode 250 g. Everything depends on how quickly the specimen is used up.