Question
Posted on: March 6 2013What is the ideal way to prepare this lotion? Which substances can be added individually to increase stability? Oleoresina capsitic 2 G progesterone 7 G Arnica tincture
15 g
chlorbutol 15 g
Zinc sulfate 3 G
copper sulfate 1 g
antiseptic solution 200 ml
and water up to 300 ml < BR/> In the preparation by the pharmacist, oil stains and precipitation occurred in a classic manner.
chlorbutol 15 g
Zinc sulfate 3 G
copper sulfate 1 g
antiseptic solution 200 ml
and water up to 300 ml < BR/> In the preparation by the pharmacist, oil stains and precipitation occurred in a classic manner.
Answer
This is a very difficult task since the composition contains a combination of organic and consequently alcoholoplovable substances with inorganic water-soluble substances. Both solvents are therefore required but water is detrimental to the solubility of organic products and alcohol of the inorganic. The oil stains observed in the preparation are derived from the capsitic and the precipitation presumably of the zinc and copper sulfate. The prescribed composition will have to be adjusted. I Cremophor RH 30 g, Oleoresina capsitic 2 G, progesterone 7 g, arnica tincture 15 g, chlorbutol 15 g; all dissolve in 150 ml of alcohol. II znsulfate 3 G and cusulphate 1 g to dissolve in 90 ml water Preparation:
pour under well stirring I at II, mix and apply to volume with water.
There is initially a cloudy that as more of I is added disappears. The solution obtained is slightly opalescent but seems usable. There are currently no data on stability. It is of course not excluded that in the future refinement is further possible on the basis of the experience gained. The proposal seems to me to be an interesting starting point.
A first procedure is the propagation of the water by reducing the amount of alcohol external use to 150 ml. To keep the capsitic and the progesterone in solution, a solubilizer is added like e.g. Cremophor RH.
The wording then looks like this:
pour under well stirring I at II, mix and apply to volume with water.
There is initially a cloudy that as more of I is added disappears. The solution obtained is slightly opalescent but seems usable. There are currently no data on stability. It is of course not excluded that in the future refinement is further possible on the basis of the experience gained. The proposal seems to me to be an interesting starting point.