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Question

Posted on: January 5 2019

Two betamethasone creams; A fat based cold cream and a hydrophilic-based image. Both contain 20% LCD. How can I prepare it?

The composition of the creams is as follows 1. Betamethasonvalerate 0.03%; Salicylic Acid 5%, LCD 20% and Beeler base AD 100 g 2. Betamethasone dipropionate 0.064%; Salicylic acid 5%; LCD 20% and cold cream AD 100 g

Answer

Cream 1 poses no heavy problems considering LCD O/W Emulgatorische features.   Betamethasone valerate and salicylic acid can be dissolved in the LCD.   After processing these alcoholic solutions in the image base   the dissolved fraction of Betamethasone valerate will be hydrolysed   under the influence of the acidic pH Set by the dissolved fraction of salicylic acid. It is therefore perhaps desirable to evaporate the alcohol and follow the method described for the cold cream.  

In Crème 2 comes the known incompatibility of LCD with W/O creams. In addition, cold cream is a little stable W/O cream. Due to the very high concentration of LCD, therefore,   should be used a cool ointment stabilized with extra W/O emulsifier and the alcohol removed.  

In a tarred round base scale, 20 g of LCD, in which Betamethasone Dipropionate and     Salicylic acid are dissolved,     mix occasionally, dry to 20 g of starch. To accelerate the evaporation of the alcohol, a hair dryer can be used. After evaporating the alcohol the mass of the evaporative remainder is determined.     This powder mixture adds the amount of stabilized cooling ointment required for 100 g cream, under good mixing in portions