Question
Posted on: March 6 2013A suspension with colistin and tobramycin sulphate is not optimal colistin sulfate 1g Tobramycine sulfate 0.8 g after CMC 200mg Glycerol 5ml purified water ad 60ml
< br/> tobramycin sulfate 1g dissolves in 50ml of water and colistin sulfate would be freely soluble & #039; in water according to Martindale & #039;. However, in water, colisitinsulfate reacts exactly like a hydrophobic substance and caked more together than to dissolve. Colistine sulfate is now moistened with glycerol and rubbed with Na CMC but the suspension is not optimal. After 10 minutes, a separation of 1 cm is already shown at the top of the suspension and after 2u (presumably) the colistin sulfate is completely precipitated. What could be missing or improved here to obtain a stable suspension?
Answer
Your observations are interesting. The cokose of colistin sulfate is caused by the reaction with CMC-. The solution is therefore to replace NaCMC with methyl cellulose (MC). So I would use the mucus solution of methyl cellulose FN 5, which can be found in the & #039; > Galenic Formularium on page 149. Methyl cellulose 2g is dissolved in 98g water for preservation. I would use this solution 10g. I do not know how it is made with the taste of this preparation. If necessary, you can use 30ml sugar syrup and replenish with purified water up to 60ml.