Question
Posted on: October 26 2016Suppositories with a high content of essential oils. Which suppository basis?
Answer
For volatile oils, which dissolve in the suppository base, we charge a melting point reduction of 0.3 °C for 1% oil; except for chloral hydrate (0.1 °C).
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for a number of problem preparations, for which there was a good solution, we are going backwards due to the lack of the appropriate resources. This is valid for the suppositories you cited. A first possibility exists in the use of yellow or white wax to increase the lowered melting point back. Camphor, Guaiacol, eucalyptol and other volatile oils in a concentration of 1% give a smeltpoint reduction of 0.3 °C while for chloral hydrate the value = to 0.1 °C. The finished suppository is best a melting point of +/-35 °C. If the melting point reduction BV is 3 °C, we need to use a mass with melting points 38 °C. The percentage of yellow wax can be read from a chart.
So you calculate the melting point reduction for your suppositories. The finished suppository has quite a melting point of +/-35 ° C. So we need a suppository mass with a stol point of 35 + melting point lowering degrees. To obtain this we add a percentage was added. We'll read this percentage on a chart you can find on
http://www.qualenica.be/vraagbox/voor-het-maken-van-bepaalde-zetpillen-heb-ik-zetpilmassa-witepsol-e85-novata-d-nodig