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Question

Posted on: April 8 2014

Suppositories Break easily

Composition of the suppositories: R/Ergotaminetart 1mg, Diphenhydramine HCl 30mg, Paracetamol (PDR) 400mg, caffeine 100mg I use Suppocire as Suppubasis as2X and make suppositories of 3g The patient complains that they break fast

Answer

There are suppository masses for suppositories with a high content of ablishing, as is   the case here. But through the normal distribution channels you will not be able to purchase them. It is like with the trains. All transport accelerates but in 2014 the duration of the train journeys is extended. I think you are now getting two suppository masses offered.  

I suspect that all solids appear as fine to very fine powder. I could possibly make some exceptions for Coffein, a hard powder that is very difficult to fine-tune. The best is to use a coffee grinder.

The only thing I see as a possibility is the addition of a small amount of Miglyol oil. I can be hard to draw up how much. A 50 mg per suppository. The total quantity (500 mg for 10 suppositories) will probably be insufficient to rub the mixture of the powders with it. But with a part it should succeed. Basically, the oil has to lower the stol point of the suppository mass slightly and maybe they break less easily.  

I have to acknowledge that it does not guarantee that this proposal solves the problem. But a highly reduced supply of raw materials limits the possibilities.