Should a pH adjustment be made for metronidazole in next regulation? Metronidazole 0.75% propylene glycol 5% Na EDTA 0.1% trometamol 0.25% polyacrylic acid 0.5%

Metronidazole splits into neutral and acidic environment by hydrolysis. Hydroxy compounds, primary and secondary amines and eventually nitrites occur. In the presence of Triethanolamine, Cancerinogenic nitrosamines can be formed. Therefore, a pH of 5 should be pursued. If the viscosity is insufficient, the amount of polyacrylic acid (CARBOPOL) can be increased.