Question
Posted on: April 18 2018Problems with the EC of capsules with acetylsalicylic acid and paracetamol and Coffein
Samenst.: levocetirizine Teva 5mg 2.5 mg, acetylsalicylic acid 250mg, Paracetamol 250mg, Coffein 5mg, Methylprednisolone 2mg, capsules + envelop 15 pcs
Problem: The problem occurs at the time of the envelope, when drying we hear a crackling sound and the capsule is ahw ' wiped '. If we envelop an empty capsule enteric there is no problem (so it is not on the capsule)
What is the cause?
Answer
The problems of cracking and cracking of capsules in the EC were already sent to me.
The declaration was then attributed to the vochtration content of the Gelulen, which should be kept in good relative humidity. I then prescribed a simple method to increase the water content of the dry gelules.
Your case is more complex due to the presence of acetylsalicylic acid, product WA
a
ROP the storage conditions and old age also have a significant influence. After all, under the influence of moisture, acetic acid can be formed. This acid is then skilled on the one hand with paracetamol but on the other
to react with the Gelulewand.
a real solution I don't have for your problem. I can only write that my gut feeling goes in the direction of acetylsalicylic acid.
The other ingredients seem To me rather innocent.
I would start by looking at what
g
Eturn when acetylsalicylic acid is omitted from the composition. In this Geva
L can apply the method described on the website to restore the moisture content of dry gelules. I would also omit the levocetirizine. I don't think that gives any problems.