Question
Posted on: April 8 2014Preparation of Nystatin aerosol for horses
We have received a veterinary prescription for nystatin 400kUI/ml in aerosol therapy (2X2ML/day). Do you have experience with this preparation. The vet thinks that glycerol is used to make the preparation. Is it possible to use Nystatin for inhalation?
Answer
article is for human medicine but can be a slip point for veterinary applications.
Bronchopulmonary Candidiasis: Clinical Aspect
S. C. Chakravarty
Author and Funding Information
Chest. 1967; 51 (6): 608-613. DOI: 10.1378/chest. 51.6.608
Abstract
1. The incidence of secondary bronchopulmonary candidiasis has been reported in 3.7 per cent in chronic bronchopulmonary diseases, but primary Bronchopulmonary Candidiasis is a rare entity. 2. Eleven patients were found to have bronchopulmonary candidiasis of which one had primary pulmonary disease. 3. Only nine patients received treatment and all improved. It is suggested that patients with chronic bronchitis who do not improve with conventional treatment be investigated for bronchopulmonary Candidiasis.
4. Suspension of sterilized Nystatin powder (50.000 units) daily in divided doses in 40 per cent propylene glycol in normal saline were given as Aero Sol.
5. Combination of oral Nystatin tablets 2 million units daily in four divided doses with aerosol of suspension of Nystatin powder (50.000 units in Four divided doses) in 40 per cent propylene glycol in normal saline solution with the help of intermittent positive pressure breathing in inspiration at pressure of 10-15 cm of H 2 O or with the help of hand nebulizer when positive pressure machine is not Available, are recommended. Treatment should be given for at least two to three weeks.