A Kligman cream is asked to prepare? Which is the composition

of the Kligman cream exist some variants. The original composition was   Hydroquina 5%, Tretinoin 0.1% and dexamethasone 0.1%. It can apparently also with 1% hydrocortisone   is another possibility with   0.1% triamcinolonacetonide   or   0.01 fluocinolonacetonide       a Complete composition for Kligman's cream is: hydroquinone 5 g, Tretinoin 100 mg, dexamethasone 100 mg, ascorbic acid   (or nametabisulfite) 0.5 g, Butylhydroxytolua 40 mg, Na2EDTA 50 mg and hydrophilic anionic cream TMF AD 100 g. No Cetomacrogol Cream   of the cream I can't find any stability data. The weak spots are Hydroquina and Tretinoin. For one, a water soluble antoxidans is used, for the second a lipophilic antoxidans to protect the double bonds.     save In the refrigerator is highly recommended and given a magistal preparation I would suggest a shelf life of 2 months. So maybe 30 g delivery?     NOTE   1. As far as Tretinoin is concerned, all   recommendations are in the TMF. Tretinoin is a dangerous well and female staff should not work with Tretinoin.     2.   Given the many small quantities, which are present in the composition, the preparation of 100 g is indicated even though the delivery of 30 g is recommended. When storing in the refrigerator,   could be a shelf life of 3 months.   So 100 g is prepared,   3 tubes Filled, 1   delivered and the 2 remaining in the fridge stored??     3. A monitoring of the shelf life is possible to the occurrence of discoloration of hydroquinone. In the breakdown of tretinoin, nothing is visible, I think.