Is it possible to process the product ethosuximide (specialty name Ethymal 250mg per caps) in Suppos?

I suspect that the processing of the contents of the capsules in suppositories poses no problems. Of course, the question must be asked whether the pharmacone is absorbed into the rectum. The following research results were published in the study of rabbits. But it is an indication anyway. Apparently, the preference should be given to a suppository mass based on PEG & #039; s.

Ethosuximide was formulated in different suppositional bases. In Vitro Release experiment to more rapid and higher release of the drug from water soluble polyethylene glycol (PEG) bases than from Witepsol fatty bases. Rectal administration in PEG 400:4000 and 400:6000 to rabbits gave high plasma levels where Cmax was 45.66 and 42.66 micrograms.ml-1, respectively; While, in the presence of Witepsol E76 and W35 it was 34.00 and 28.33 micrograms.ml-1, respectively. The systemic availability was 89.39%, 82.72%, 58.80% and 47.45% when the bases were PEG 400:4000, PEG 400:6000, Witepsol E76 and Witepsol W35, respectively.