Question
Posted on: March 6 2013I have a few questions regarding these nasal drops: Phenylefrine HCL 2.5 g Naphazoline HCl 1 G chlorbutol 5 G Menthol 200 mg Eucalyptol 5 dr Glycerin 20 ml
Tween 80 10 Dr
Propylene glycol 20 ml
water AD 1 L < BR/> should glycerol and propylene glycol be counted for isotonic? For 20 ml glycerin and 20 ml propylene glycol, 7.21 g and 9.27 G NaCl should be required for 1 L isotonic solution, respectively. The result is that these nasal droplets are enormously hypertone. Is it right that you already make 20 mL glycerol 0.8 l of water Hypertone?
Propylene glycol 20 ml
water AD 1 L < BR/> should glycerol and propylene glycol be counted for isotonic? For 20 ml glycerin and 20 ml propylene glycol, 7.21 g and 9.27 G NaCl should be required for 1 L isotonic solution, respectively. The result is that these nasal droplets are enormously hypertone. Is it right that you already make 20 mL glycerol 0.8 l of water Hypertone?
Answer
I can't follow your calculations. I start with the conversion of volumes to Mass & #039; s and note that 20 ml glycerin = 25.3 g and 20 ml propylene glycol = 20.7 g. In the lists "Isotonic Solutions" in the Merck Index I set 26 g Glycerin and 21 g propylene glycol to give an isotonic solution. So we can argue that the nasal drops are 2 x hypertone. So both quantities must be halved.
the solubility of Chlorbutol in water is 1 to 100 to 1 on 1000 so probably just soluble in the amount of water. While menthol and eucalyptol are not this and need to be solubilized. Ten drops of Tween 80 seems to me a bit to the tight side and consequently I would double this amount.
the solubility of Chlorbutol in water is 1 to 100 to 1 on 1000 so probably just soluble in the amount of water. While menthol and eucalyptol are not this and need to be solubilized. Ten drops of Tween 80 seems to me a bit to the tight side and consequently I would double this amount.
I dare suppose that this is an old formulation. But there is some to note about these nasal drops when we consider the modern insights.
Nafazolinenitraat We can better replace it with a modern vasoconstrictor such as Xylomethazoline. Chlorbutol, I fear, can best be completely omitted given its crippling effect on the nose vibrate.