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Question

Posted on: March 6 2013

I had a question about following preparation: Hydrocortisone acetate 1g prednisolone 0.3 g liquor Carbonis detergent 9g urea 3g lipophilic cream TMF AD 100g

< br/> The liquor Carbonis detergent (O/W) cannot be processed here in the fat base (the quantity is too large). The CR è me always breaks, even after adding extra W/O emulsifier. Is there a possibility that liquor carbonis detergent can be processed in the lipophilic CR è me or should a different basis be chosen srfing?

Answer

I am a little she that you do not come to a good result after adding extra W/O emulsifier. It is important that you take the LCD in a cooled lipophilic cr è me. In addition to the remark, which you make about the emulgatorical properties of LCD, we also have to refer to the negative effect of the alcohol, which is contained in LCD. Therefore following method.

rub in a tarred metal or porcelain dish, the prednisolone and the hydrocortisone acetate with the LCD and then evaporate on a lightly heated plate the alcohol of the LCD. The weight difference is replaced by starch, which is mixed under the contents of the scale. Note the total weight mixture (eg = X) in the scale and calculate the amount of various constituents needed for the preparation of a total of 97-X g lipophilic cr è me. Prepare this amount of CR è me and dissolve the 3 G urea in the water phase. Let this cr è me completely cool and rub the powder mass in the bowl with this urea-containing lipophilic cr è me.

an alternative method would exist to replace the weight difference obtained after evaporating the alcohol by Arlacel C. Roughly along the lines of what you already did.