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Question

Posted on: March 6 2013

I am looking for a compound for an aqueous solution of vitamin E following a prescription for 2 month baby.

Dosage 75 IU/ml, posology: 0.7 ml per day for 2 months.

Answer


In A text, found on the APB website, for vitamin E the conversion of units to MG is treated. The expression of the vitamin E-activity is quite complex because a set of natural isomers exist that each possess a variable biological activity. The vitamin E activity can be expressed in two ways (1):
  • The old standard, the international unit, is defined as that amount equivalent to 1 mg of DL-α-tocopherol acetate, a synthetic derivative of the Of course, vitamin E. In principle, this standard was already abandoned in 1956, but is still widely used in practice every day.
  • the new standard is based on the biologically most active form D-α-tocopherol, the natural isomer (RRR-α-tocopherol). 1 mg D-α-tocopherol is defined as 1 D-α-tocopherol equivalent (α-TE).
Between the old definition and the new units, and taking into account the ester or the isomer, we have following conventions (1) (2)   IE α-TE 1 mg DL- α-tocopherol acetate 1 0.67 1 mg DL-α-tocopherol hydrogenosuccinate 0.89 0.58 1 mg DL-α-tocopherol 1.1 0.74 1 mg D- α-tocopherol acetate 1.36 0.90 1 mg D-α-tocopherol 1.49 1 1 mg D-α-tocopherol hydrogenosuccinate 1.21 0.82

Bassron sells tocopherol acetate; I suspect the DL-α-tocopherol acetate (falls check). In this case, 1 IU = 1 mg; This means 75 mg/ml or 2.25 g/30ml. I would try the next composition in which vitamin E is solubilised in water.

R/K sorbate 90mg
Citric acid 80mg
Tween 80 4g
Vitamin E oil 2.25 g
anise oil 80mg
sugar syrup 4.2 g
water up to 30ml