To recipes helpdesk

Question

Posted on: March 6 2013

I am looking for a composition for the preparation of 1% 5-fluorouracil Collyre (fluoracedyl).

Answer

As a starting product we use Flurobastine 500mg solution 10ml for injection. The following data can be found about this product:

List of excipients
sodium hydroxide
Water for injectable preparations.

shelf Life
2 years.

Special precautions for storage
store at room temperature (15 °-25 ° C), protected from light. 5-Fluorouracil should not be exposed for long at temperatures higher than 35 ° C and less than 10 ° C.

For the preparation of 10ml eye drops we need 2ml of the Flurobastine solution and we can dilute it with 8ml sterile physiological serum in a sterilized eye dropper vial. This operation should be carried out in aseptic conditions.