Question
Posted on: August 4 2015How do I prepare Suppositoria Glycerini USP?
Also still called "hard glycerin suppositories" I thought the composition is the following: Glycerin 90 g; After stearate 9% and water 5 g
The method of preparation would be as follows:
Glycerol on hot water bath up to 95 ° heating: After Stearate sieves and in glycerol joints; Mix with glass rod slowly stirring (when hard stirring foaming) until solution is clear; Add the heated water; Pour out the warm mass in suppository form which is heated to 80 °.
Answer
The USP publishes the following on these suppositories:
» Glycerin Suppositories contain Glycerin solidified with Sodium Stearate . [ Note — If preferred, the Sodium Stearate for Glycerin Suppositories may be prepared during the making of the Suppositories by the direct reaction between Stearic Acid and Sodium Bicarbonate, Sodium Carbonate, or Sodium Hydroxide, these being tasks in the correct proportion. ] Glycerin Suppositories contain not less than 75.0 percent and not more than 90.0 percent, by weight, or Glycerin (C 3 H 8 O 3 ).
Packaging and storage — preserve in Well-closed containers.
Action and medical uses. These suppositories, by the irritating presence of the glycerin, provoke rectal action, causing an intestinal evacuation. They are USEFY-ul in some cases of constipation depending on the Cicero of the lower bowel. They should NOT be used continuously.
Apparently, here are suppositories of +/-6 g meant. But the alveoli of our European suppository forms for adults usually have a volume of 2 ml. Converted with the density of glycerin it corresponds to a mass of 2.6 g. Consequently, we prepare 30 g suppository Mass, which we eventually divide over 10 suppositories. Because of the lack of post-stearate, we proceed as follows:
1. Place the suppository form on the hot water bath
2. Weigh in a zetpilpan 30 g glycerin and add 1.5 g after carbonate anhydrous (supplied by ACA Pharma) And let it dissolve on a hot water bath.
3. Add 2.5 g stearic acid; stir and heat gently until it has been dissolved and the exemption from CO2 stops
4. Fill the cavities of the suppository form with the warm liquid mass and let it cool completely slowly
5. Wrap each suppository in aluminum foil because of the hygroscopic nature of the suppositories