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Question

Posted on: September 23 2016

How do I prepare folic acid capsules 1 mg According to the latest guidelines of the online version of the TMF?

The online version of the TMF organizes the preparation of folic acid capsules other than the previous version

Answer

The TMF describes

1. A 2% trituration

Rp/ folic acid 1.00 g *   diluent B Q.S. ad 50.0 g   * on the basis of the actual active substance content, an exact quantity corresponding to 1.00 g of anhydrous folic acid must be weighed 2. Preparation of   30 capsules   BV 4 mg Rp/ folic acid 4 mg *   diluent B Q.S. for 1 Gelule *   In The form of a 2% trituration of folic acid. Preparation method:   weigh 6.30 g from a 2% trituration of folic acid (5% overdose included to compensate for the loss during preparation * ) ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- calculation for 50 capsules   1 mg folic acid; The folic acid has a content = 97.3% and a water content of 7.82%   A. Calculation of water-free raw material 1 g raw material contains 0.9218 anhydrous folic acid with a content of 97.3%   b. Calculation of the real content of folic acid in the water-free raw material 0.9218 x (97,3/100) = 0.869   Pure Folic acid C. Preparation of Trituration 2%   needed 2 x (1/0,869) = 2.3 g raw material for 100 g trituring being 1.15 g raw material for 50 g trituring   D.   Preparation of 50 capsules of folic acid 1 mg; for this I need 50 x 1 mg = 50 mg folic acid; 1 g trituration contains 20 mg of folic acid so I need 2.5 g trituration. E. Compensation for loss (5% extra) so I weigh  : 2.5 g X 1.05 = 2.625 g of the 2% trituration