Question
Posted on: March 6 2013An erythromycin solution with Zn acetate in ethanol exhibits precipitation: erythromycin 4g Zinc acetate 1g propylene glycol 10g ethanol 65 ° 45ml WATER AD 100ml
< br/> We dissolve erythromycin in ethanol, zinc acetate in water with propylene glycol and add ammonium acetate, when mixing 2 solutions we get a cloudy thick liquid. How is this and is that normal? When preparing according to TMF (isopropanol) We get a clear liquid, is this better?
Answer
The precipitation has to do with the formation of Zn (OH) 2, which must be brought back in solution by complexation of Zn + + with ammonium. Perhaps more ammonium acetate solution should be added in the case of ethanol? It is clear that preference should be given to the TMF formula, which was validated.