To recipes helpdesk

Question

Posted on: March 6 2013

A chloramphenicol suspension for a child with a risk of meningitis: chloramphenicol 1700mg, excipient AD 100ml.

We have attempted to suspend chloramphenicol with xanthan gum, with no result (subsiding).

Answer

Your question makes me clear that chloramphenicol has disappeared completely from medicine, so to speak. Maybe good though. Now in emergencies, it still remains an interesting antibiotic. First of all, a suspension based on chloramphenicol is not to be adopted either by a child or by an adult! We use the water insoluble ester chloramphenicolpalmitate. For this there is a good formula for a suspension. These can be found in the Galenic Formularium  . It is worked secundum the Precisive method of having chloramphenicol in the right polymorphic form, which is best absorbed.