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Question

Posted on: October 28 2015

Can a stock solution be prepared with Urfamycine?

Prescription NKO-Doctor: 12 vials of Urfamycine 750mg each time dissolve in 5ml solvent for injection + 40 ml Pulmicort 0.5 mg/ml (20 amp) + 100ml physiological serum = 200 ml. Is This stock solution stable, can it be stored in the refrigerator?

Answer

  How to store Urfamycine

store at room temperature (15-25 °C). The prepared solution is usable for several hours at room temperature.  

There is such a thing as the Q10 rule, which says that the stability of a product doubles for every ten degrees we reduce the temperature. The reverse works of course as well.

So suppose at room temperature (20 °C) 2 hours stable; at 10 degrees 4 hours and at-5 ° C +/-  10 hours.    

Pulmicort is a suspension and for this product is clearly indicated do not freeze. After all, a lowering of the temperature can   make changes to the particle size by lowering the dissolved fraction. Little is completely insoluble!!

I fear that the client will have to compose his solution for inhalation itself, taking into account the quantities and proportions prescribed by the physician.