Can levetiracetam be processed in a Suppo?

Pharmacokinetics of Levetiracetam after rectal administration in healthy volunteers

Objective: To Investigate whether rectal administration is an alternative for oral administration by comparing the pharmacokinetics of Levetiracetam after single-dose rectal versus oral administration in healthy volunteers. Design: Single-centre, open-label, single-dose, crossover study. Methods: We included 13 healthy volunteers who received a Levetiracetam 500 mg tablet and after a washout period of at least 7 days, a Levetiracetam 500 mg suppository. Blood samples were collected before administration and several times within the first 24 hours after administration of the tablet or suppository, to quantify levetiracetam plasma concentrations. WinNonlin was used to analyse the data. Results: A One-compartment model was suitable for both oral and rectal administration. The AUC of oral and rectal administration was 6406 vs 6690 mg · L-1 · min (p = 0557). The mean relative bioavailability (AUCrectal/AUCoral) was 104% (SD 23). It took more time to reach maximum peak concentration for the suppository (T max 190 vs 78 min), resulting also in a lower maximum concentration for the rectal administration (Cmax 7.56 vs 11.65 mg/ml). Conclusion: Rectal Administration is an alternative for oral administration, since there was no significant difference in bioavailability (AUC). Follow-up research should include multi-dose administration and patients with epilepsy. Pharmacokinetics or Levetiracetam after rectal administration in healthy volunteers | Request PDF . Available from: https://www.researchgate.net/publication/289201747_Pharmacokinetics_of_levetiracetam_after_rectal_administration_in_healthy_volunteers [Accessed Jan 16 2018].

The rectal administration therefore seems to be an alternative to the oral pathway. You must leave from film-coated tablets that you must crush into powder. The best method, which also others have already used in such cases, is grinding with an electric coffee grinder. The obtained powder is sieved and what remains on the sieve are mainly chunks of the film layer. One can try to grind the sieve rest a second time and to seven. Are the film leftovers not to get fine then they are removed.