Anyone have experience with nystatin in zinc oxide paste?

Normally we focus on the ' official ' designations of the Formularia. Zinc oxide paste (or Zn-Oxide dough) = Pasta Zinci Oxydi BF 5. Water paste = Pasta aquosa FN5 does not mention ZnO in the BENAMNG and. Contains no ZnO. I would therefore certainly not take this into account for this requirement. You can also opt for the variety without a wool grease and then you come to the name Pasta Zinci from TMF.

More importantly, the stability of Nystatin. Nystatin is not completely insoluble in water and the dissolved part is thus subject to degradation In the literature it is mentioned that starting from the preparation Nystatin begins to break down. The optimal pH = 7 and preservation is done in the refrigerator. ZnO will set a higher pH. The formula below shows that Nystatin contains an acidic carboxyl function, which will form a Zn salt with ZnO. A replacement by TiO2 can be considered. I Mmers the different mode of response between TiO ₂ and ZnO can be derived among others from the different place of Ti and Zn in the table of Mendeljev and also from their different solubility in diluted acids where ZnO is soluble in diluted acids and TiO ₂ not.

So there is reason to avoid water and make use of a vehicle that does not contain water so the fatty paste. The Nystatin preparation is stored in the refrigerator. Dissolution manifests itself by the occurrence of a brown color.  

 

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