Question
Posted on: January 19 2019Anyone have experience with lisinopril suspension 1mg/ml from Zestril tablets?
Answer
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Zestril tablets contain the following excipients: mannitol, calcium hydrogen phosphate dihydrate, red iron oxide (E172), cornstarch, pregelatinised starch, magnesium stearate The pregelised starch will swell in contact with water and give a certain viscosity to the environment. Following composition can be prepared Zestril tabltet 20 mg 10 tablets water 10 ml citric acid 4.2 g Na citrate 3.0 g xanthan gum 400 mg after Saccharinate 300 mg K sorbate 200 mg sorbitol 10 g water AD 200 ml In a bottle, 200 ml of water is poured and the surface is marked with a marker on the wall of the bottle. The bottle is emptied. Zestril tablets are crushed and finely rubbed into a mortar. The powder is sieved; What remains on the sieve is further finely rubbed and after seven joined the rest. All powder is transferred into a bottle and moistened with 10 ml of water. Xanthan gum is mixed with sorbitol and the mixture is then rubbed with 50 ml of water, in which citric acid is dissolved. The mucus is transferred into the bottle and the mortar is rinsed with 50 ml of water. After Saccharinate, K sorbate and after citrate are weighed and transferred into the bottle. The whole is mixed by shaking with the bottle. The suspension in the bottle is supplemented with water until the applied gauge. NOTE the alkaline calcium hydrogen phosphate increases the pH of the suspension medium so that a citric acid citrate buffer should be added to ensure the antimicrobial action of sorbic acid. This buffer sets the pH of the suspension to a value of 4.3 to 4.4. The suspension is 6 weeks shelf life.