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Question

Posted on: March 6 2013

After a day lies the green color at the bottom of this syrup:

Pholcodine 0.4 g ethanol 5 ml codeine phosphate and ephedrine HCl AA 300 mg promethazineHCl 100 mg ascorbic acid 200 mg, after citrate 5 g, citric acid 2 G, Sirupus simplex 65 g, water AD 200 ml.

supplement This solution with Eucalyptolsyrup up to 300ml. < BR/>

Answer

(obtained in collaboration with pharmacist A. Demeulenaere)

Presumably we have to do with a pH problem. After alkalinizing the solution to pH = 7, there is much less precipitation which indicates that the problem is indeed situated in the dye (water soluble salt of chlorophyll), which is present in the used eucalyptol syrup and precipitates at an acidic pH. Given a pH = 7 or higher is not favorable for the stability of Promethazine is best chosen for another dye. We find these in Eucalyptolsyrup NF VI with as dye: solutio viridis = patent Blue + tartrazine. But given patent blue is no longer available, use Certa's green nutritional dye. This color turns yellow in acid and blue in alkaline middle; At approximately pH 5 the solution becomes green.