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Question

Posted on: March 6 2013

Please provide a method of preparation for Imiquimod 5% suppo and vaginal ovule.

Answer

I suppose you will use Aldara cr è me, given the raw material is not available in Vrac. This CR è me is O/W. For ovulation, I do not see such a big problem because we have the possibility to use a hydrophilic mass such as the glycerin gelatin mass. This mass is less common for suppositories. For the suppositories I would try to evaporate in light heating and using a warm airflow the water phase as much as possible and mix the evaporative residue with a melted suppository mass like Witepsol W45.