Suppositories with Lorazepam or flunitrazepam give a problem of subsiking.

You can purchase Lorazepam 5g at Bassron. The suppositories should contain 2.5 mg of lorazepam. Prepare with this product a dilution 1 to 50 in powdered lactose with addition of a tell-tale. Then add the amount of trituration 2g extra lactose powder to use and mix. Take all these quantities into account when calculating the amount of suppository mass to weigh. Mix the obtained mixture with half the amount of melted suppository base, which you need. Then transfer this mixture into your cast pan and homogenize.