Question
Posted on: September 21 2020How do I use Liquifine® ?
Answer
Liquifine® makes it possible to produce high quality pharmaceutical suspensions in an easy manner.
Therefore, you first have to check the compatibility of your active ingredient with Liquifine®. The table below can help you with this decision. For all the components in this table, there are also detailed production protocols available on the 'Recipe Helpdesk'.
|
Storage |
Liquifine® pH4 Liquid |
Liquifine® pH4 Liquid + NaHCO3 |
Liquifine® Alkalic dry |
Acetazolamide |
RT |
V |
|
|
Baclofen |
RT |
V |
|
|
Domperidone |
RT |
V |
|
|
Furosemide |
RT |
|
V |
|
Furosemide |
Fridge |
|
|
V |
Hydrocortison |
RT |
V |
|
|
Metronidazole |
RT |
V |
|
|
Omeprazole |
Fridge |
|
V |
V |
Paracetamol |
RT |
V |
|
|
Tetracycline HCl |
RT |
V |
|
|
Trimethoprim |
RT |
V |
|
|
Vancomycine HCl |
Fridge |
V |
|
|
Preparation instructions:
Liquifine® pH4 Liquid 500 ml
Weigh the required quantity of active substance and reduce the particles to a fine powder by the use of a mortar and vessel, if necessary.
Humidify the powder with a limited quantity of Liquifine® and homogenize.
Add Liquifine®, following the geometric dilution method, to the desired volume.
Label the recipient with 'Shake before use'.
Liquifine® pH4 Liquid 500 ml + NaHCO3
Weigh the required quantity of active substance, as wel as 4.04 g sodium hydrogencarbonate (per 100 mL suspension), and homogenize.
Humidify the powder with a limited quantity of Liquifine® and homogenize.
Add Liquifine®, following the geometric dilution method, to the desired volume.
Label the recipient with 'Shake before use'.
Liquifine® Alkalic dry
Weigh the required quantity of Liquifine® Alkalic dry (6.3 g per 100 mL suspension) and transfer it to the final recipient*.
Weigh the required quantity of active substance and transfer it also to the final recipient.
Shake firmly.
Add purified water to the desired volume and shake firmly until a homogeneous dispersion is obtained.
Label the recipient with 'Shake before use'.
* You can also use the pre-filled 100 mL bottles with mark line, which contain already the required amount of Liquifine® Alkalic dry.
As you can see, it is possible to use Liquifine® pH4 Liquid 500 mL + NaHCO3 as well as Liquifine Alkalic dry for the processing of acid sensitive components. The overview below can help you to make the right choice for your application.
Liquifine® pH4 Liquid |
Liquifine® Alkalic dry |
|
|
Preservative free Cheaper Handy container |